Mpho Louisa Phalatse is a South African medical doctor and politician who was the Executive Mayor of the City of Johannesburg Metropolitan Municipality. A member of the Democratic Alliance, she has served in the position from 22 November 2021 until her ousting in a motion of no-confidence on 26 January 2023. She is the first woman to serve as mayor of the metropolitan municipality, which was established in 2000. She is the first black woman to serve as mayor of the city of Johannesburg and only the second female mayor of the city after Jessie McPherson, who served from 1945 to 1946.
From 2016 to 2019, Phalatse had served as the member of the mayoral committee (MMC) in Johannesburg for Health and Social Development.